My favourite video game is Gothic 1 + 2 and also Risen (currently waiting for Risen 2 )
Mass Effect is close to them but I'm grown up with Gothic and played it a long time so it stays in my head among the good old times.
My favorite game right now is a tie between Persona 3 and 4, due to the story, character interaction, and the turn-based combat a lot of modern RPGs forsake.
Resident Evil 1 (Original of 1996)
Metal Gear Solid 4 Guns of the patriots
Gothic 1,2 and 3
Fable 1 and 2
The legend of Zelda series
Silent Hill 1
Star Ocean The last Hope INTERNATIONAL
Left4Dead 1 and 2
Half Life 2
Battlefield Bad Company 2 Multiplayer
So....
Witcher (waiting for witcher2),
Total War games
TES IV (waiting for TES V),
Mass Effect 1/2,
Dark Messiah,
Assassin's Creed (2,3 have not played yet)
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By the way SHOGUN 2 is out now! I'm going to buy in a couple of days. It will be something! Saw the video reviews - there are no words. I think anime fans should enjoy the war in medieval Japan))